On Wednesday, aTyr Pharma, Inc. (NASDAQ: ATYR) had a 26.14% increase in its stock price at $6.61. The dramatic rise came after the business revealed that the last patient in its worldwide Phase 3 EFZO-FIT clinical study had finished their last visit.
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In this trial, individuals with pulmonary sarcoidosis—one of the most common types of interstitial lung disease—are being evaluated for efzofitimod, aTyr’s principal treatment candidate. The third quarter of 2025 is when the pivotal trial’s topline results are anticipated.
A Significant Development in the Sarcoidosis Study
The EFZO-FIT trial is the largest interventional study ever carried out for patients with sarcoidosis and the first worldwide Phase 3. Tyr Pharma views this accomplishment as a significant turning point for the business and the larger sarcoidosis community.
The majority of sarcoidosis treatments now available rely on oral corticosteroids, which can have crippling adverse effects. Efzofitimod may be validated as a treatment that can lower steroid use while improving patient quality of life, according to the EFZO-FIT study.
Positive Signals in Systemic Sclerosis Trial
In a separate development last month, aTyr Pharma shared interim results from its Phase 2 EFZO-CONNECT study, which is assessing efzofitimod in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD).
Preliminary data from eight participants revealed encouraging signals in skin-related outcomes, particularly the modified Rodnan Skin Score (mRSS)—a key measure of skin fibrosis. All patients showed either stability or improvement in mRSS, and three of four patients with the more severe diffuse SSc-ILD exhibited notable clinical progress within 12 weeks.
Looking Ahead to Expanded Data and Trial Completion
The EFZO-CONNECT trial continues to enroll patients as it moves toward its 24-week endpoints. With lung function as the primary measure for ILD outcomes, aTyr Pharma aims to provide further updates upon study completion. The ongoing clinical advancements suggest a robust future pipeline for the company’s immunology-based therapeutic platform.
